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Proceedings Papers

Alteration of Genome Structure Induced by Very Low Dose-Rate Irradiation in Mouse Tissues

Authors:

Tetsuya Ono ,

Dept of Cell Biology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan, JP
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Yoshihiko Uehara,

Dept of Cell Biology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan, JP
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Naohito Okudaira,

Dept of Cell Biology, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan, JP
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Kazuo Fujikawa,

Faculty of Science and Technology, Kinki University, Osaka, Japan, JP
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Nao Kagawa,

Faculty of Science and Technology, Kinki University, Osaka, Japan, JP
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Mitsuaki Yoshida,

National Institute of Radiological Science, Chiba, Japan, JP
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Isamu Hayata,

National Institute of Radiological Science, Chiba, Japan, JP
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Takehiko Nohmi,

National Institute of Health Science, Tokyo, Japan, JP
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Tsuneya Matsumoto,

Institute for Environmental Sciences, Aomori, Japan, JP
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Yoichi Oghiso,

Institute for Environmental Sciences, Aomori, Japan, JP
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Kimio Tanaka,

Institute for Environmental Sciences, Aomori, Japan, JP
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Kazuaki Ichinohe,

Institute for Environmental Sciences, Aomori, Japan, JP
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Shingo Nakamura,

Institute for Environmental Sciences, Aomori, Japan, JP
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Satoshi Tanaka

Institute for Environmental Sciences, Aomori, Japan, JP
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Abstract

To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 ?Gy/min, which resulted in total doses of 21, 414, and 8,000 mGy, respectively. Statistically significant increases were observed for all indices examined when the total dose was 8,000 mGy, whereas no significant difference was observed with 21 mGy or 414 mGy.
DOI: http://doi.org/10.2481/dsj.BR-05
How to Cite: Ono, T. et al., (2009). Alteration of Genome Structure Induced by Very Low Dose-Rate Irradiation in Mouse Tissues. Data Science Journal. 8, pp.PBR36–PBR41. DOI: http://doi.org/10.2481/dsj.BR-05
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Published on 23 Jun 2009.
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